Interleukin-6(IL-6) is a multifuctional cytokine and deregulated IL-6 gene expession has been implicated as being involved in the pathogenesis of a number of disease. Tissue-plasminogen acgivator (t-PA) is serine protease which secreted in most
tumor
cell line and participates in extracellular tissue degradation of tumor cell.
So we measured the blood levels of IL-6 & t-PA to elucidate the relationship between IL-6, t-PA and stage of cervical carcinoma and evaluate the value of IL-6 and t-PA as new tumor marker in cervical carcinoma.
The blood levels of IL-6 & t-PA were measured in 60 patients admitted to the Severance hospital, from August, 1992 to February, 1993, of whom 30 patients were diagnosed as invasive cancer of the cervix, 20 as CIN, and 10 controls.
The average serum level of IL-6 & t-PA in invasive cervical cancer, CIN and control person were respectively 30.33 pg/ml, 29.20 pg/ml 12.45 pg/ml and 6.15 ng/ml, 4.61ng/ml and 5.00ng/ml. In 20% of invasive cervical cancer patients(6/30), and 15%
of
CIN
patients (30/20) studied blood levels of IL-6 were detected whereas only 20% of control persons showed the same results. But the level of t-PA was detected in all groups.
These results suggest the solitary tumor markers of IL-6 and t-PA is not justified and need more factors to use as new tumor markers.
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